8/6/2023 0 Comments Keykey asociation![]() Plus when covid arrived, residents again were told to take part in a deep clean, there was a poster stating gloves and masks will be provided, They were not provided, Also there was no disinfection to clean with, just fairy liquid. Also first week I was here, all residents were told we all have to take part in a deep clean throughout this house, Yet no gloves were provided, no disinfection, i nearly threw up, and to this day I rarely use the kitchen. The matress is very uncomfortable staff told me to buy matress topper. I looked at my matress it was covered in urine stain staff turned it over and this side was also covered in urine stains, I said I cant sleep on that staff got me a used one from another houses. My bed, There is no headboard staff told me to buy extra pillows. Dirty carpet, plus dirt all round the skirting board, first I asked staff if the carpet can be cleaned, staff said no so I asked staff another time, can my carpet, and skirting board be cleaned, staff said sure it can, never did get cleaned. ![]() First day I moved In I was so shocked, my room has a high celling which I can't reach, there were a load of long thick cobwebs hanging down, i asked staf it took three months before they found someone trained to use a stepladder before the webs were moved. I'm completely sick of it and can't stand it any longer.ĭo not move into supported sanctury housing From when i moved in to present day, Just pointing out a few things, out of many. So now that I can't use the restroom and don't have a kitchen, where is the help? I'm disgusted by the fact that I have to go through this again and be treated in this manner. I already have a health problem, and now I have to deal with this as well. How would I be able to cook if my kitchen is destroyed, but Sanctuary customer service continues to tell me that we can send you to a food bank? Where is the logic in that? The worst part is that the bathroom is leaking again, and they are informing me that no one can come out until the 5th of June because it is not an emergency. They have refused to offer me any meal vouchers, insisting that I should go to food bank. My kitchen is now being renovated, and I am unable to cook. They decanted me and my family again, and we was in a hotel for around 3 months. ![]() During this period, they put my family and me in a hotel for about a month. Conclusion This research illustrated a cuproptosis-related hub gene PDHB which could serve as a potential prognostic marker and provide therapeutic benefits for clinical treatment of ccRCC patients.Currently, I am a tenant at Sanctuary Housing Association. I've had a problem with them because of a leak from my bathroom into my kitchen. They originally came out and renovated my bathroom, but they didn't do a good job, so I had to complain when it started to leak again. Subsequent studies showed that copper-induced cell death activation could overcome sunitinib resistance in RCC cells. Mechanistically, knockdown PDHB appeared to promote the RCC cells proliferation, migration, and invasion potentials. Additionally, low PDHB was negatively correlated with Treg cells, indicating an immunosuppressive microenvironment. Clinicopathological parameters and tissue microarray (TMA) indicated that PDHB was identified as a prognostic factor for survival outcomes among ccRCC patients. Results PDHB mRNA and protein expression level was significantly downregulated in ccRCC tissues compared with normal and paired normal tissues. The functional significance and clinical association of PDHB was validated with loss of function experiments and surgical removal specimens. The dysregulation of PDHB in ccRCC was characterized, together with survival outcomes, pathway enrichment and immune infiltration among tumor microenvironments. Methods Using Single-cell RNA-seq, bulk transcriptome and other multi-omics datasets, we identify essential cuproptosis-related hub gene PDHB for further study. The present study aimed to discover the biological function of cuproptosis regulators with the potential to guide clinical therapy. However, the underlying mechanism of cuproptosis with molecular heterogeneity and tumor microenvironment (TME) in ccRCC remains to be elucidated. Accumulating evidence revealed that copper-induced cell death played a vital role in various tumors. You just subscribed to receive the final version of the articleīackground Renal clear cell carcinoma (ccRCC) is one of the most prevalent cancers worldwide.
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